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An antibiotic-resistant strain of the bacteria that causes typhoid fever has spread to many countries and reached epidemic levels in Africa, a new study warns.
The strain, H58, emerged in South Asia between 25 and 30 years ago and has slowly grown to become one of the predominant forms of the bacteria Salmonella Typhi, said study author Vanessa Wong, a microbiologist at the University of Cambridge in England.”This multidrug-resistant strain, H58, is resistant to a number of first-line antibiotics used to treat the disease and is continuing to evolve and acquire new mutations to newer drugs,” Wong said.
Typhoid presents no direct threat to people living in the United States, where clean water supplies
and good sanitation prevent exposure to the bacteria, said Dr. Henry Chambers, chief of infectious diseases at San Francisco General Hospital and a professor at the Unive
Access to high-quality medicine is a basic human right, but more than four
billion people live in countries where many medications are substandard or fake. Marya Lieberman of the Department of Chemistry and Biochemistry at the University of Notre Dame and Abigail Weaver, a postdoctoral associate in the University’s Department of Civil Engineering and Environmental and Earth Sciences, took up the challenge of how people in developing countries could detect low-quality antimalarial drugs without expensive equipment and without handling dangerous chemicals.
The solution they developed involves using paper cards, embedded with reagents,
Patients with chronic heart failure, a disabling, deadly disease that worsens as the heart gradually pumps less
efficiently, are getting a much-needed new option with U.S. approval Wednesday of a novel drug from Amgen Inc.
Corlanor is the first medication in a dozen years for heart failure, which is becoming more common with obesity – and more people surviving heart attacks due to better treatments.
Meanwhile, the Food and Drug Administration is reviewing another heart failure pill, from Novartis AG, and could approve it this summer.
More than 5 million Americans and more than 25 million people worldwide have heart failure, which kills up to half of patients within five years, despite numerous generic pills and other treatments available. It costs the global economy an estimated $108 billion annually, mostly for repeated hospitalizations, so preventing those is a key cost-control target.
For most patients, it’s a chronic condition, caused by high blood pressure or other factors damaging heart muscle. That leaves many patients with “low-ejection fraction,” meaning the heart’s main pumping chamber can’t push out anywhere near the 50 percent or more of blood a healthy heart ejects.
Symptoms include breathlessness, fatigue and fluid retention. That keeps many patients homebound and causes repeated emergency department visits, often in the middle of the night, due to infections or just straying from a low-salt diet.
“It’s not uncommon for these people to be hospitalized two to 12 times a yearR
The state Commissioner for Health, Dr. Dayo Adeyanju, who confirmed the casualty figures to journalists in Akure, the state capital, said four other persons were being given isolated treatment at the General Hospital in the town.
He said unconfirmed reports on Thursday morning said two out of the four patients undergoing treatment in isolated clinic had died.
University of Notre Dame researchers led an international team to identify a molecular mechanism responsible for
making malaria parasites resistant to artemisinins, the leading class of antimalarial drugs.
According to the World Health Organization’s 2014 World Malaria Report, there are an estimated 198 million cases of malaria worldwide with 3.3 billion people at risk for contracting the infection. Although the impact of malaria is still significant, the statistics reflect a considerable reduction in the global malaria burden. Since 2010, disease transmission has been reduced by 30 percent and mortality due to malaria has decreased by almost half.
Artemisinins are powerful drugs that have the most rapid action of all current drugs against Plasmodium falciparum, the parasite speci
Why naked? Because the drug sends body temperatures skyrocketing to as high as 106 degrees, which prompts users who have taken too much to rip away their clothes during sweating, delusional fits.
“They strip off their clothes and run outdoors, acting very violent with adrenaline-surged strength,” said Jim Hall, an epidemiologist at the Center for Applied Research on Substance Use and Health Disparities at Nova Southeastern University in Broward County, Fla.
A quick-acting, single-dose Ebola vaccine is safe and effective in nonhuman primates, and may lead to a new human vaccine, U.S. researchers reported Wednesday.
The experimental vaccine is effective against the West African Makona strain of Ebola Zaire virus, which to date has infected more than 25,000 people — killing nearly 10,600 — in the ongoing outbreak in Africa.
New data on the harm caused by foodborne illnesses underscore the global threats posed by
unsafe foods, and the need for coordinated, cross-border action across the entire food supply chain, according to WHO, which next week is dedicating its annual World Health Day to the issue of food safety.
World Health Day will be celebrated on 7 April, with WHO highlighting the challenges and oppo
When caring for people with diabetes, primary care
doctors need to tailor blood sugar targets and treatments to the individual patient, new recommendations suggest.
That’s just one of the guidelines highlighted in an article that experts from the Joslin Diabetes Center in Boston published in the March 23 issue of the Annals of Internal Medic
Treating respiratory disease is often difficult because drugs have to cross biological barriers such as
respiratory tissue and mucosa, and must therefore be given in large quantities in order for an effective amount to reach the target.
Now researchers from Germany, Brazil and France have shown that the use of nanoparticles to carry antibiotics across biological barriers can be effective in treating lung infections. Doing so allows better delivery of the drug to the site of infection, and hence prevents the development of antibiotic resistance which may be caused by too large and continued doses of antibiotic. Additionally, such a strategy might help to overcome the rapid metabolism and excretion of the antibiotic from the body, which happens when it is administered by traditional routes, either orally or intravenously.
Describing her team’s work to the 13th European Respiratory Society Lung Science C
Though pharmaceutical companies would like you to believe that stomach acid is just a nuisance that needs to be neutralized, stomach acid actually plays a very essential part in our digestive process. If stomach acid didn’t have any use, it wouldn’t exist in healthy individuals. To this point, people with health issues are much more likely to have low levels of stomach acid than healthy individuals. To be sure, having proper levels of stomach acid is completely normal for human beings. In fact, without proper levels of hydrochloric acid in the stomach, our body can’t absorb nutrients nearly as well.