On Monday we looked at the application of celecoxib in post surgical patients with respect to other NSAIDs, we got very lively answers from contributors, but for the records Nonsteroidal anti-inflammatory drugs (NSAIDs) are a
group of structurally unrelated organic acids that have analgesic, anti-inflammatory, and antipyretic properties NSAIDs are inhibitors of the enzyme cyclo-oxygenase, and so directly inhibit the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. There are 2 forms of cyclo-oxygenase (COX), COX-1, which is the constitutive form of the enzyme, and COX-2, which is the form induced in the presence of inflammation. Inhibition of COX-2 is therefore thought to be responsible for at least some of the analgesic, anti-inflammatory, and antipyretic properties of NSAIDs whereas inhibition of COX-1 is thought to produce some of their toxic effects, particularly those on the gastrointestinal tract. Most of the NSAIDs currently available for clinical use inhibit both COX-1 and COX-2, although selective COX-2 inhibitors such as celecoxib are now available.
Blood platelets represents the first line of host defence when normal cells are injured,and this platelet aggregation is mediated in part by constitutively expressed cyclo-oxygenase I, when inhibited by non-selectively NSAIDs, as shown in the pictures, it predisposes one to bleeding. However, selective NSAIDs does not inhibit cox1,thus excluding the side effects of bleeding while retaining the analgesic effects of NSAIDs. This is the most probable reason the pharmacist changed the take-home drugs to celecoxib.
If you missed the question, click THE celecoxib
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