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Here comes the answer 48…the celecoxib

Here comes the answer 48…the celecoxib

On Monday we looked at the application of celecoxib in post surgical patients with respect to other NSAIDs, we got very lively answers from contributors, but for the records Nonsteroidal anti-inflammatory drugs (NSAIDs) are a
group of structurally unrelated organic acids that have analgesic, anti-inflammatory, and antipyretic properties NSAIDs are inhibitors of the enzyme cyclo-oxygenase, and so directly inhibit the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. There are 2 forms of cyclo-oxygenase (COX), COX-1, which is the constitutive form of the enzyme, and COX-2, which is the form induced in the presence of inflammation. Inhibition of COX-2 is therefore thought to be responsible for at least some of the analgesic, anti-inflammatory, and antipyretic properties of NSAIDs whereas inhibition of COX-1 is thought to produce some of their toxic effects, particularly those on the gastrointestinal tract. Most of the NSAIDs currently available for clinical use inhibit both COX-1 and COX-2, although selective COX-2 inhibitors such as celecoxib are now available.

mechanism of action

mechanism of action


Blood platelets represents the first line of host defence when normal cells are injured,and this platelet aggregation is mediated in part by constitutively expressed cyclo-oxygenase I, when inhibited by non-selectively NSAIDs, as shown in the pictures, it predisposes one to bleeding. However, selective NSAIDs does not inhibit cox1,thus excluding the side effects of bleeding while retaining the analgesic effects of NSAIDs. This is the most probable reason the pharmacist changed the take-home drugs to celecoxib.
If you missed the question, click THE celecoxib
We appreciate the responses from Chinonye and obiyindo, as well as Pharmacist Audu,who wrote in for us to learn more,you guys rock!!!
Join us every Monday for can you deliver series,and Fridays for here comes the answer series,we expect your replies to the questions and your criticisms to our answers. If you have any experience as a pharmacist, a medical doctor,a nurse, scientist,physiotherapist etc that you think will help improve learning ,you can email them to us at ugwulekecc@gmail.com for publication
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Can you deliver 48: the celecoxib…guest write in

Can you deliver 48: the celecoxib…guest write in

I personally want to appreciate you for the wonderful work you are doing with this wonderful series, since I started following it, I must confess, I have learnt a whole lot. Ensure you keep it.
I went to the hospital to visit a friends wife who was delivered of a baby through a Caesarian, on our arrival, we met with the doctor, in his office ( it was a private hospital), while he was congratulating my friend for a successful surgery and explaining how difficult it was…but in all, we thank God it was successful. We now decided to go see our wife, when we got to her private ward, the nurse told the doctor their pharmacist said the diclofenac which was part of her take home drug should be changed to Celecoxib, the doctor said, if the pharmacist said give celecoxib, then give that.
The question I want to ask now is, what was going on in the pharmacist’s mind
Pharmacist Audu wrote in from Jos, plateau state Nigeria.

Join us every Monday for can you deliver series,and Fridays for here comes the answer series,we expect your replies to the questions and your criticisms to our answers. If you have any experience as a pharmacist, a medical doctor,a nurse, scientist,physiotherapist etc that you think will help improve learning ,you can email them to us at ugwulekecc@gmail.com for publication
Do not forget to like our page on facebook,
follow on twitter @futurerxdream or @ugwuleke

BBM channel C002D3B6D
NOTE; Every first and last fridays of the month would be interns focused questions. read more

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