On Monday we looked at the application of celecoxib in post surgical patients with respect to other NSAIDs, we got very lively answers from contributors, but for the records Nonsteroidal anti-inflammatory drugs (NSAIDs) are a
group of structurally unrelated organic acids that have analgesic, anti-inflammatory, and antipyretic properties NSAIDs are inhibitors of the enzyme cyclo-oxygenase, and so directly inhibit the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. There are 2 forms of cyclo-oxygenase (COX), COX-1, which is the constitutive form of the enzyme, and COX-2, which is the form induced in the presence of inflammation. Inhibition of COX-2 is therefore thought to be responsible for at least some of the analgesic, anti-inflammatory, and antipyretic properties of NSAIDs whereas inhibition of COX-1 is thought to produce some of their toxic effects, particularly those on the gastrointestinal tract. Most of the NSAIDs currently available for clinical use inhibit both COX-1 and COX-2, although selective COX-2 inhibitors such as celecoxib are now available.
If you missed the question, click THE celecoxib
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